Public Health and Safety

THC & Neuropsychiatric Symptoms in Adults Age 50+ (Feb 2021)

In the February 2, 2021 edition of Jama Network Open, a study titled, “Evaluation of THC-Related Neuropsychiatric Symptoms Among Adults Aged 50 Years and Older, A Systematic Review and Metaregression Analysis” (Velayudhan et.al.) was released. While there are numerous studies that examine youth / young adults, marijuana use and adverse mental health issues, this study examines the same issues in adults age 50 and older.

Using set dosing levels of THC (20mg, 10mg and 2.3mg) researchers established that there was a “… significant positive association…” of these THC dosage levels and “light-headedness and perception disorder”. The authors note that perception disorders were found in 2 of the numerous studies used in the report.

In their findings the authors note that, in addition to the increase incident risk ratios from use, that adults over 50 should exercise caution in using THC due to increased risk of fall from “light-headedness and dizziness”. No association with other neuropsychiatric adverse effect was reported by participants and further studies into this area are needed.

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